We suggest inhibiting the first phrase out-of area step 3

We surmise that results obtained from the experiments described in this section cannot serve to understand the role of I_NaL in arrhythmogenesis.

step one. Van Driessche W, Lindemann B: Attention reliance out-of currents as a consequence of solitary salt-choosy pores during the frog facial skin. Nature. 1979; 282 (5738): 519-520 PubMed Abstract | Blogger Complete Text

It means brand new solid findings put forward by this manuscript is perhaps not rationalized and that i don’t agree the fresh new manuscript inside form

The writers has actually explained a number of the questions We increased inside my earlier comment. Regrettably, all the biggest difficulties haven’t been treated through this revision. Whenever i stated in my past remark, I deem it unrealistic that every people situations can be repaired only of the several extra paragraphs. Rather you can still find certain practical questions into the experimental design and you may, most vitally, with the study.

This means brand new solid findings submit by this manuscript is maybe not rationalized and that i try not to agree the fresh manuscript within this setting

This new writers has actually made clear several of the inquiries I increased in my personal previous comment. Unfortunately, all significant difficulties have not been treated from this update. Whenever i manufactured in my personal earlier feedback, We deem they impractical that all those individuals affairs will likely be repaired just because of the a few extra sentences. Rather you may still find some standard concerns with the experimental build and you will, really vitally, into investigation.

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• Best issue is that in case I implemented the malfunction out of the methods in the earlier variation it had been you’ll be able to to help you decode, that have almost perfect accuracy, any arbitrary stimuli labels We chosen. Select to possess types of which reanalysis. Regardless of whether we pretend the actual stimuli featured within an after big date otherwise was constantly switching ranging from laws and you will silence, the new decoding is always alongside prime. This really is an indication the decryption doesn’t have anything accomplish for the real stimuli heard by Sender it is opportunistically exploiting some other provides about investigation. The latest manage studies the fresh writers performed, reversing the stimulus labels, usually do not target this problem because it is suffering from similar problem. Generally, what the classifier is allegedly using is the time having passed once the recording become.
• The reason for that is allegedly that the authors put low-separate analysis to own education and you may evaluation. And if I know truthfully (look for area 3), random sampling half of data examples out of an EEG shadow commonly independent research. Repeated the study five times – the fresh new control data the newest authors performed – isn’t an acceptable answer to target that it matter. Randomly wanting samples regarding a time show containing slow transform (like the slow wave hobby you to allegedly reigns over this type of tracks not as much as these scenarios) will inevitably include good temporal correlations. Pick TemporalCorrelations.jpg set for 2D occurrence histograms and you will a correlation matrix demonstrating it.
• Once the modified tips point provides increased detail today, it continues to be confused about exactly what research were used. Conventional category research statement exactly what data has actually (common columns throughout the research matrix) and you can exactly what findings (usual rows) were used. Some thing might be an element but normally this is the fresh new various other EEG channels otherwise fMRI voxels an such like. Findings are time activities. Right here I suppose the brand new authors switched the latest intense products into the good some other place using dominating parts investigation. This is not said in the event the dimensionality is smaller by using the eigenvalues. In either case, I suppose the content trials (gathered during the 128 Hz) was in fact after that used because observations in addition to EEG channels switched from the PCA were used since the keeps. The latest stimuli labels were tasked because the With the or Regarding per decide to try. A couple of 50% off products (and you will names) ended up being chosen randomly for training, together with people was utilized getting assessment. Is it best?